Anti-FHOD1 antibody (Full-Length) [M352] (STJA0041229)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFHOD1 recombinant protein that included the full length human FHOD1 sequence. This sequence has 50% homology to human FHOD3, and low homology to other formin family members.
General Information
| Short Description | Mouse monoclonal anti-FHOD1 (Full-Length) for use in ELISA, WB and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M352 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein A Purified |
| Dilution Range | WB 1:250IHC 1:50 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
Target Information
| Gene Symbol | FHOD1 |
| Gene ID | 29109 |
| Uniprot ID | FHOD1_HUMAN |
| Immunogen | FHOD1 recombinant protein that included the full length human FHOD1 sequence. This sequence has 50% homology to human FHOD3, and low homology to other formin family members. |
| Immunogen Region | Full-Length |
| Immunogen Sequence | Human |
| Specificity | The antibody detects a 140 kDa* protein corresponding to the apparent molecular mass of FHOD1 on SDS-PAGE immunoblots of human K562 and Jurkat, and has weak reactivity to FHOD1 in mouse C2C12. |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in spleen. |
| Post Translational Modifications | Phosphorylated by ROCK1. |
| Function | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. |
| Protein Name | Fh1/Fh2 Domain-Containing Protein 1Formin Homolog Overexpressed In Spleen 1FhosFormin Homology 2 Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionBlebPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Fh1/Fh2 Domain-Containing Protein 1 antibodyAnti-Formin Homolog Overexpressed In Spleen 1 antibodyAnti-Fhos antibodyAnti-Formin Homology 2 Domain-Containing Protein 1 antibodyAnti-FHOD1 antibodyAnti-FHOS antibodyAnti-FHOS1 antibody |
Information sourced from Uniprot.org