Anti-FHL2 antibody (C-Term) (STJ70520)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-FHL2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 30kDa band observed in Human and Mouse Heart lysates (calculated MW of 32.2kDa according to NP_001441.4). Recommended concentration: 1-3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FHL2 |
| Gene ID | 2274 |
| Uniprot ID | FHL2_HUMAN |
| Accession Number | NP_001441.4 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RDDILCPDCGKDI |
| Specificity | Reported variants represent identical protein (NP_001441.4; NP_963849.1; NP_963851.2; NP_001034581.1). |
Additional Info
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. |
| Protein Name | Four And A Half Lim Domains Protein 2Fhl-2Lim Domain Protein DralSkeletal Muscle Lim-Protein 3Slim-3 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Four And A Half Lim Domains Protein 2 antibodyAnti-Fhl-2 antibodyAnti-Lim Domain Protein Dral antibodyAnti-Skeletal Muscle Lim-Protein 3 antibodyAnti-Slim-3 antibodyAnti-FHL2 antibodyAnti-DRAL antibodyAnti-SLIM3 antibody |
Information sourced from Uniprot.org