Anti-FGF19 antibody (25-216) (STJ28672)

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STJ28672
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Short Description :Rabbit polyclonal FGF19 (25-216) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:100-1:500
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:FGF19
Gene ID:9965
Uniprot ID:FGF19_HUMAN
Immunogen Region:25-216
Immunogen Sequence:LAFSDAGPHVHYGWGDPIRL RHLYTSGPHGLSSCFLRIRA DGVVDCARGQSAHSLLEIKA VALRTVAIKGVHSVRYLCMG ADGKMQGLLQYSEEDCAFEE EIRPDGYNVYRSEKHRLPVS LSSAKQRQLYKNRGFLPLSH FLPMLPMVPEEPEDLRGHLE SDMFSSPLETDSMDPFGLVT GLEAVRSPSFEK
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 25-216 of human FGF19 (NP_005108.1).
Tissue Specificity Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Function Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Protein Name Fibroblast Growth Factor 19
Fgf-19
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1307965
Reactome: R-HSA-190322
Reactome: R-HSA-2219530
Reactome: R-HSA-5654228
Reactome: R-HSA-5654712
Reactome: R-HSA-5654719
Reactome: R-HSA-5654720
Reactome: R-HSA-5654733
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Cellular Localisation Secreted
Alternative Antibody Names Anti-Fibroblast Growth Factor 19 antibody
Anti-Fgf-19 antibody
Anti-FGF19 antibody
Anti-UNQ334 antibody
Anti-PRO533 antibody

Information sourced from Uniprot.org