| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FGF13 |
| Gene ID: |
2258 |
| Uniprot ID: |
FGF13_HUMAN |
| Immunogen Region: |
1-245 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human FGF13 (NP_004105.1). |
| Immunogen Sequence: |
MAAAIASSLIRQKRQARERE KSNACKCVSSPSKGKTSCDK NKLNVFSRVKLFGSKKRRRR RPEPQLKGIVTKLYSRQGYH LQLQADGTIDGTKDEDSTYT LFNLIPVGLRVVAIQGVQTK LYLAMNSEGYLYTSELFTPE CKFKESVFENYYVTYSSMIY RQQQSGRGWYLGLNKEGEIM KGNHVKKNKPAAHFLPKPLK VAMYKEPSLHDLTEFSRSGS GTPTKSRSVSGVLNGGKSM |
| Tissue Specificity | Ubiquitously expressed. Predominantly expressed in the nervous system. |
| Post Translational Modifications | May be phosphorylated. |
| Function | Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. |
| Protein Name | Fibroblast Growth Factor 13Fgf-13Fibroblast Growth Factor Homologous Factor 2Fhf-2 |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: CytoplasmNucleusIsoform 3: CytoplasmIsoform 4: CytoplasmIsoform 5: CytoplasmCell ProjectionFilopodiumGrowth ConeDendriteCell MembraneSarcolemmaCytoplasmNot SecretedLocalizes To The Lateral Membrane And Intercalated Disks Of Myocytes |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor 13 antibodyAnti-Fgf-13 antibodyAnti-Fibroblast Growth Factor Homologous Factor 2 antibodyAnti-Fhf-2 antibodyAnti-FGF13 antibodyAnti-FHF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
