Anti-FERMT1 antibody (C-Term) (STJA0005772)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from the C-terminal region of human URP1.
General Information
| Short Description | Rabbit polyclonal anti-URP1 (C-Term) for use in WB in Bovine, Canine, Human, Mouse, Non-Human Primates, Rat and Xenopus samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Bovine/Canine/Human/Mouse/Non-Human Primates/Rat/Xenopus |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FERMT1 |
| Gene ID | 55612 |
| Uniprot ID | FERM1_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from the C-terminal region of human URP1. |
| Immunogen Region | C-Term |
| Specificity | Reacts with the C-terminal region of the 77 kDa human URP1 protein. Sequence is 100% conserved between almost all species (mouse, rat, canine, bovine, chimpanzee, Xenopus). |
Additional Info
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. |
| Protein Name | Fermitin Family Homolog 1KindlerinKindlin Syndrome ProteinKindlin-1Unc-112-Related Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideConstituent Of Focal AdhesionsLocalized At The Basal Aspect Of Skin KeratinocytesClose To The Cell MembraneColocalizes With Filamentous ActinUpon Tgfb1 TreatmentIt Localizes To Membrane Ruffles |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 1 antibodyAnti-Kindlerin antibodyAnti-Kindlin Syndrome Protein antibodyAnti-Kindlin-1 antibodyAnti-Unc-112-Related Protein 1 antibodyAnti-FERMT1 antibodyAnti-C20orf42 antibodyAnti-KIND1 antibodyAnti-URP1 antibody |
Information sourced from Uniprot.org