| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Promotes ubiquitination and degradation of SLBP. |
| Protein Name | Protein Fem-1 Homolog CFem1cFem1-Gamma |
| Database Links | Reactome: R-HSA-8951664 |
| Alternative Antibody Names | Anti-Protein Fem-1 Homolog C antibodyAnti-Fem1c antibodyAnti-Fem1-Gamma antibodyAnti-FEM1C antibodyAnti-KIAA1785 antibody |
Information sourced from Uniprot.org
