Anti-FDXR antibody (252-491) (STJ23645)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FDXR (252-491) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FDXR |
| Gene ID | 2232 |
| Uniprot ID | ADRO_HUMAN |
| Immunogen Region | 252-491 |
| Immunogen Sequence | PILDPVDFLGLQDKIKEVPR PRKRLTELLLRTATEKPGPA EAARQASASRAWGLRFFRSP QQVLPSPDGRRAAGVRLAVT RLEGVDEATRAVPTGDMEDL PCGLVLSSIGYKSRPVDPSV PFDSKLGVIPNVEGRVMDVP GLYCSGWVKRGPTGVIATTM TDSFLTGQMLLQDLKAGLLP SGPRPGYAAIQALLSSRGVR PVSFSDWEKLDAEEVARGQG TGKPREKLVDPQEMLRLLG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3). |
Additional Info
| Function | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6. |
| Protein Name | Nadph -Adrenodoxin Oxidoreductase - MitochondrialArAdrenodoxin ReductaseFerredoxin--Nadp(+ ReductaseFerredoxin Reductase |
| Database Links | Reactome: R-HSA-196108Reactome: R-HSA-211976Reactome: R-HSA-2395516Reactome: R-HSA-5579026 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Nadph -Adrenodoxin Oxidoreductase - Mitochondrial antibodyAnti-Ar antibodyAnti-Adrenodoxin Reductase antibodyAnti-Ferredoxin--Nadp(+ Reductase antibodyAnti-Ferredoxin Reductase antibodyAnti-FDXR antibodyAnti-ADXR antibody |
Information sourced from Uniprot.org