Anti-FDFT1 antibody [R07-9J7] (STJA0036683)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human FDFT1
General Information
| Short Description | Rabbit monoclonal anti-FDFT1 for use in WB, IHC-P, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-9J7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FDFT1 |
| Gene ID | 2222 |
| Uniprot ID | FDFT_HUMAN |
| Immunogen | A synthesized peptide derived from human FDFT1 |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. |
| Protein Name | Squalene SynthaseSqsSsFpp -Fpp FarnesyltransferaseFarnesyl-Diphosphate FarnesyltransferaseFarnesyl-Diphosphate Farnesyltransferase 1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Squalene Synthase antibodyAnti-Sqs antibodyAnti-Ss antibodyAnti-Fpp -Fpp Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase 1 antibodyAnti-FDFT1 antibody |
Information sourced from Uniprot.org