| Short Description : | Rabbit monoclonal SQS/FDFT1 (150-250) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FDFT1 |
| Gene ID: | 2222 |
| Uniprot ID: | FDFT_HUMAN |
| Immunogen Region: | 150-250 |
| Immunogen Sequence: | MGIGMAEFLDKHVTSEQEWD KYCHYVAGLVGIGLSRLFSA SEFEDPLVGEDTERANSMGL FLQKTNIIRDYLEDQQGGRE FWPQEVWSRYVKKLGDFAKP E |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SQS/FDFT1 (P37268). |
| Tissue Specificity | Widely expressed. |
| Function | Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. |
| Protein Name | Squalene SynthaseSqsSsFpp -Fpp FarnesyltransferaseFarnesyl-Diphosphate FarnesyltransferaseFarnesyl-Diphosphate Farnesyltransferase 1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Squalene Synthase antibodyAnti-Sqs antibodyAnti-Ss antibodyAnti-Fpp -Fpp Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase 1 antibodyAnti-FDFT1 antibody |
Information sourced from Uniprot.org
