Anti-FCRL5 antibody (16-190) (STJ115746)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FCRL5 (16-190) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCRL5 |
| Gene ID | 83416 |
| Uniprot ID | FCRL5_HUMAN |
| Immunogen Region | 16-190 |
| Immunogen Sequence | QFARTPRPIIFLQPPWTTVF QGERVTLTCKGFRFYSPQKT KWYHRYLGKEILRETPDNIL EVQESGEYRCQAQGSPLSSP VHLDFSSASLILQAPLSVFE GDSVVLRCRAKAEVTLNNTI YKNDNVLAFLNKRTDFHIPH ACLKDNGAYRCTGYKESCCP VSSNTVKIQVQEPFT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 16-190 of human FCRL5 (NP_001182317.1). |
Additional Info
| Tissue Specificity | Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). |
| Function | Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization. |
| Protein Name | Fc Receptor-Like Protein 5Fcr-Like Protein 5Fcrl5Bxmas1Fc Receptor Homolog 5Fcrh5Immune Receptor Translocation-Associated Protein 2Cd Antigen Cd307e |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fc Receptor-Like Protein 5 antibodyAnti-Fcr-Like Protein 5 antibodyAnti-Fcrl5 antibodyAnti-Bxmas1 antibodyAnti-Fc Receptor Homolog 5 antibodyAnti-Fcrh5 antibodyAnti-Immune Receptor Translocation-Associated Protein 2 antibodyAnti-Cd Antigen Cd307e antibodyAnti-FCRL5 antibodyAnti-FCRH5 antibodyAnti-IRTA2 antibodyAnti-UNQ503 antibodyAnti-PRO820 antibody |
Information sourced from Uniprot.org