| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FCN1 (30-326) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCN1 |
| Gene ID: |
2219 |
| Uniprot ID: |
FCN1_HUMAN |
| Immunogen Region: |
30-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-326 of human FCN1 (NP_001994.2). |
| Immunogen Sequence: |
ADTCPEVKVVGLEGSDKLTI LRGCPGLPGAPGPKGEAGVI GERGERGLPGAPGKAGPVGP KGDRGEKGMRGEKGDAGQSQ SCATGPRNCKDLLDRGYFLS GWHTIYLPDCRPLTVLCDMD TDGGGWTVFQRRMDGSVDFY RDWAAYKQGFGSQLGEFWLG NDNIHALTAQGSSELRVDLV DFEGNHQFAKYKSFKVADEA EKYKLVLGAFVGGSAGNSLT GHNNNFFSTKDQDNDVSSS |
| Tissue Specificity | Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. |
| Function | Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. |
| Protein Name | Ficolin-1Collagen/Fibrinogen Domain-Containing Protein 1Ficolin-AFicolin-AlphaM-Ficolin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-2855086Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedCell MembranePeripheral Membrane ProteinExtracellular SideFound On The Monocyte And Granulocyte Surface |
| Alternative Antibody Names | Anti-Ficolin-1 antibodyAnti-Collagen/Fibrinogen Domain-Containing Protein 1 antibodyAnti-Ficolin-A antibodyAnti-Ficolin-Alpha antibodyAnti-M-Ficolin antibodyAnti-FCN1 antibodyAnti-FCNM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
