| Post Translational Modifications | Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination. |
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. |
| Protein Name | F-Bar Domain Only Protein 2 |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | MembraneClathrin-Coated PitPeripheral Membrane ProteinCytoplasmic SideAssociated With Forming But Not Mature Clathrin-Coated VesiclesThe Recruitment To Coated-Pits Precede The One Of Clathrin And The Adaptor Protein Complex Ap-2 |
| Alternative Antibody Names | Anti-F-Bar Domain Only Protein 2 antibodyAnti-FCHO2 antibody |
Information sourced from Uniprot.org
