| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNTTIP2 (1-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNTTIP2 |
| Gene ID: |
30836 |
| Uniprot ID: |
TDIF2_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DNTTIP2 (NP_055412.2). |
| Immunogen Sequence: |
MVVTRSARAKASIQAASAES SGQKSFAANGIQAHPESSTG SDARTTAESQTTGKQSLIPR TPKARKRKSRTTGSLPKGTE PSTDGETSEAESNYSVSEHH DTILRVTRRRQILIACSPVS SVRKKPKVTPTKESYTEEIV SEAESHVSGISRIVLPTEKT TGARRSKAKSLTDPSQESHT EAISDAETSSSDISFSGIAT RRTRSMQRKLKAQTEKKDSK IVPGNEKQIVGTPVNSEDS |
| Tissue Specificity | Widely expressed with higher levels in testis. |
| Function | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Deoxynucleotidyltransferase Terminal-Interacting Protein 2Estrogen Receptor-Binding ProteinLpts-Interacting Protein 2Lpts-Rp2Terminal Deoxynucleotidyltransferase-Interacting Factor 2Tdif2Tdt-Interacting Factor 2 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Deoxynucleotidyltransferase Terminal-Interacting Protein 2 antibodyAnti-Estrogen Receptor-Binding Protein antibodyAnti-Lpts-Interacting Protein 2 antibodyAnti-Lpts-Rp2 antibodyAnti-Terminal Deoxynucleotidyltransferase-Interacting Factor 2 antibodyAnti-Tdif2 antibodyAnti-Tdt-Interacting Factor 2 antibodyAnti-DNTTIP2 antibodyAnti-ERBP antibodyAnti-TDIF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89098/357557/STJ11100026_1__69013.1713121681.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
