| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IgG receptor FcRn large subunit p51 (146-196 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCGRT |
| Gene ID: |
2217 |
| Uniprot ID: |
FCGRN_HUMAN |
| Immunogen Region: |
146-196 aa |
| Specificity: |
This antibody detects endogenous levels of FCGRN at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human FCGRN at the amino acid range 146-196 |
| Function | Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. |
| Protein Name | Igg Receptor Fcrn Large Subunit P51FcrnIgg Fc Fragment Receptor Transporter Alpha ChainNeonatal Fc Receptor |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndosome Membrane |
| Alternative Antibody Names | Anti-Igg Receptor Fcrn Large Subunit P51 antibodyAnti-Fcrn antibodyAnti-Igg Fc Fragment Receptor Transporter Alpha Chain antibodyAnti-Neonatal Fc Receptor antibodyAnti-FCGRT antibodyAnti-FCRN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
