Anti-FCGR3B antibody (90-170 aa) (STJ192518)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 90-170
General Information
| Short Description | Rabbit polyclonal anti-Low affinity immunoglobulin gamma Fc region receptor III-B (90-170 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCGR3B |
| Gene ID | 2215 |
| Uniprot ID | FCG3B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 90-170 |
| Immunogen Region | 90-170 aa |
| Specificity | FCG3B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B antibodyAnti-Fc-Gamma Riii-Beta antibodyAnti-Cd16-I antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiib antibodyAnti-Fcriii antibodyAnti-Fcriiib antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-1 antibodyAnti-Cd Antigen Cd16b antibodyAnti-FCGR3B antibodyAnti-CD16B antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org