| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FCGR3B (1-233) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCGR3B |
| Gene ID: |
2215 |
| Uniprot ID: |
FCG3B_HUMAN |
| Immunogen Region: |
1-233 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3). |
| Immunogen Sequence: |
MWQLLLPTALLLLVSAGMRT EDLPKAVVFLEPQWYSVLEK DSVTLKCQGAYSPEDNSTQW FHNENLISSQASSYFIDAAT VNDSGEYRCQTNLSTLSDPV QLEVHIGWLLLQAPRWVFKE EDPIHLRCHSWKNTALHKVT YLQNGKDRKYFHHNSDFHIP KATLKDSGSYFCRGLVGSKN VSSETVNITITQGLAVSTIS SFSPPGYQVSFCLVMVLLFA VDTGLYFSVKTNI |
| Tissue Specificity | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. |
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B antibodyAnti-Fc-Gamma Riii-Beta antibodyAnti-Cd16-I antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiib antibodyAnti-Fcriii antibodyAnti-Fcriiib antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-1 antibodyAnti-Cd Antigen Cd16b antibodyAnti-FCGR3B antibodyAnti-CD16B antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
