Anti-FCGR3B antibody (1-233) (STJ110203)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FCGR3B (1-233) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCGR3B |
| Gene ID | 2215 |
| Uniprot ID | FCG3B_HUMAN |
| Immunogen Region | 1-233 |
| Immunogen Sequence | MWQLLLPTALLLLVSAGMRT EDLPKAVVFLEPQWYSVLEK DSVTLKCQGAYSPEDNSTQW FHNENLISSQASSYFIDAAT VNDSGEYRCQTNLSTLSDPV QLEVHIGWLLLQAPRWVFKE EDPIHLRCHSWKNTALHKVT YLQNGKDRKYFHHNSDFHIP KATLKDSGSYFCRGLVGSKN VSSETVNITITQGLAVSTIS SFSPPGYQVSFCLVMVLLFA VDTGLYFSVKTNI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3). |
Additional Info
| Tissue Specificity | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. |
| Post Translational Modifications | Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-BFc-Gamma Riii-BetaCd16-IFc-Gamma RiiiFc-Gamma RiiibFcriiiFcriiibFcr-10Igg Fc Receptor Iii-1Cd Antigen Cd16b |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted After Cleavage |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B antibodyAnti-Fc-Gamma Riii-Beta antibodyAnti-Cd16-I antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiib antibodyAnti-Fcriii antibodyAnti-Fcriiib antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-1 antibodyAnti-Cd Antigen Cd16b antibodyAnti-FCGR3B antibodyAnti-CD16B antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org