Anti-FAM173B antibody (1-233) (STJ29540)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FAM173B (1-233) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATPSCKMT |
| Gene ID | 134145 |
| Uniprot ID | ACKMT_HUMAN |
| Immunogen Region | 1-233 |
| Immunogen Sequence | MEGGGGIPLETLKEESQSRH VLPASFEVNSLQKSNWGFLL TGLVGGTLVAVYAVATPFVT PALRKVCLPFVPATTKQIEN VVKMLRCRRGSLVDIGSGDG RIVIAAAKKGFTAVGYELNP WLVWYSRYRAWREGVHGSAK FYISDLWKVTFSQYSNVVIF GVPQMMLQLEKKLERELEDD ARVIACRFPFPHWTPDHVTG EGIDTVWAYDASTFRGREKR PCTSMHFQLPIQA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FAM173B (NP_954584.2). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. |
| Protein Name | Atp Synthase Subunit C Lysine N-MethyltransferaseProtein N-Lysine Methyltransferase Fam173bHfam173b |
| Database Links | |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinLocalizes To Mitochondrial Cristae |
| Alternative Antibody Names | Anti-Atp Synthase Subunit C Lysine N-Methyltransferase antibodyAnti-Protein N-Lysine Methyltransferase Fam173b antibodyAnti-Hfam173b antibodyAnti-ATPSCKMT antibodyAnti-FAM173B antibody |
Information sourced from Uniprot.org