Anti-FCER2 antibody (48-321 aa) [S5017RM] (STJ11105017)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Low Affinity Immunoglobulin Epsilon Fc Receptor (48-321 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5017RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCER2 |
| Gene ID | 2208 |
| Uniprot ID | FCER2_HUMAN |
| Immunogen Region | 48-321 aa |
| Immunogen Sequence | DTTQSLKQLEERAARNVSQV SKNLESHHGDQMAQKSQSTQ ISQELEELRAEQQRLKSQDL ELSWNLNGLQADLSSFKSQE LNERNEASDLLERLREEVTK LRMELQVSSGFVCNTCPEKW INFQRKCYYFGKGTKQWVHA RYACDDMEGQLVSIHSPEEQ DFLTKHASHTGSWIGLRNLD LKGEFIWVDGSHVDYSNWAP GEPTSRSQGEDCVMMRGSGR WNDAFCDRKLGAWVCDRLA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 48-321 of human CD23 (NP_001993.2). |
Additional Info
| Tissue Specificity | Detected in urine (at protein level). |
| Post Translational Modifications | N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorBlast-2C-Type Lectin Domain Family 4 Member JFc-Epsilon-RiiImmunoglobulin E-Binding FactorLymphocyte Ige ReceptorCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecretedAlso Exists As A Soluble Excreted FormScd23 |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Epsilon Fc Receptor antibodyAnti-Blast-2 antibodyAnti-C-Type Lectin Domain Family 4 Member J antibodyAnti-Fc-Epsilon-Rii antibodyAnti-Immunoglobulin E-Binding Factor antibodyAnti-Lymphocyte Ige Receptor antibodyAnti-Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form antibodyAnti-FCER2 antibodyAnti-CD23A antibodyAnti-CLEC4J antibodyAnti-FCE2 antibodyAnti-IGEBF antibody |
Information sourced from Uniprot.org