Anti-FCER1G antibody (19-86) (STJ114755)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FCER1G (19-86) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCER1G |
| Gene ID | 2207 |
| Uniprot ID | FCERG_HUMAN |
| Immunogen Region | 19-86 |
| Immunogen Sequence | LGEPQLCYILDAILFLYGIV LTLLYCRLKIQVRKAAITSY EKSDGVYTGLSTRNQETYET LKHEKPPQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 19-86 of human FCER1G (NP_004097.1). |
Additional Info
| Function | Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit GammaFc Receptor Gamma-ChainFcrgammaFc-Epsilon Ri-GammaIge Fc Receptor Subunit GammaFceri Gamma |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837Reactome: R-HSA-5621480Reactome: R-HSA-6798695Reactome: R-HSA-75892 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma antibodyAnti-Fc Receptor Gamma-Chain antibodyAnti-Fcrgamma antibodyAnti-Fc-Epsilon Ri-Gamma antibodyAnti-Ige Fc Receptor Subunit Gamma antibodyAnti-Fceri Gamma antibodyAnti-FCER1G antibody |
Information sourced from Uniprot.org