| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBXO7 (353-522) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXO7 |
| Gene ID: |
25793 |
| Uniprot ID: |
FBX7_HUMAN |
| Immunogen Region: |
353-522 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 353-522 of human FBXO7 (NP_036311.3). |
| Immunogen Sequence: |
LSLSAVCRDLFTASNDPLLW RFLYLRDFRDNTVRVQDTDW KELYRKRHIQRKESPKGRFV MLLPSSTHTIPFYPNPLHPR PFPSSRLPPGIIGGEYDQRP TLPYVGDPISSLIPGPGETP SQFPPLRPRFDPVGPLPGPN PILPGRGGPNDRFPFRPSRG RPTDGRLSFM |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2. Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains. Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death. |
| Protein Name | F-Box Only Protein 7 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusMitochondrionCytosolPredominantly CytoplasmicA Minor Proportion Is Detected In The NucleusRelocates From The Cytosol To Depolarized Mitochondria |
| Alternative Antibody Names | Anti-F-Box Only Protein 7 antibodyAnti-FBXO7 antibodyAnti-FBX7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
