Anti-FBXO45 antibody (STJA0004363)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human FBXO45
General Information
| Short Description | Rabbit polyclonal anti-F-Box/Spry Domain-Containing Protein 1 for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:200 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | FBXO45 |
| Gene ID | 200933 |
| Uniprot ID | FBSP1_HUMAN |
| Immunogen | Synthetic peptide of human FBXO45 |
Additional Info
| Function | Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but also plays an important role in assembly of the complex. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism. Plays a role in the regulation of neurotransmission at mature neurons. May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome. Also acts by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation. Induces subsequently an increase in mitotic slippage and prevents mitotic cell death. In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain. |
| Protein Name | F-Box/Spry Domain-Containing Protein 1F-Box Only Protein 45Hfbxo45 |
| Database Links | |
| Cellular Localisation | SecretedPostsynaptic Cell MembranePresynaptic Cell MembraneNucleusSecreted By A Non-Classical Mechanism |
| Alternative Antibody Names | Anti-F-Box/Spry Domain-Containing Protein 1 antibodyAnti-F-Box Only Protein 45 antibodyAnti-Hfbxo45 antibodyAnti-FBXO45 antibodyAnti-FBX45 antibody |
Information sourced from Uniprot.org