Anti-FBXO43 antibody (STJA0007989)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FBXO43
General Information
| Short Description | Rabbit polyclonal anti-F-box only protein 43 for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBXO43 |
| Gene ID | 286151 |
| Uniprot ID | FBX43_HUMAN |
| Immunogen | Synthesized peptide derived from human FBXO43 |
| Specificity | This antibody detects endogenous levels of FBXO43 at Human, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation. Ubiquitinated in response to calcium, which promotes proteasomal degradation. |
| Function | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. |
| Protein Name | F-Box Only Protein 43Endogenous Meiotic Inhibitor 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-F-Box Only Protein 43 antibodyAnti-Endogenous Meiotic Inhibitor 2 antibodyAnti-FBXO43 antibodyAnti-EMI2 antibody |
Information sourced from Uniprot.org