Anti-FBXO4 antibody (Internal) (STJ72184)

SKU:
STJ72184-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-FBXO4 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-2.5µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: FBXO4
Gene ID: 26272
Uniprot ID: FBX4_HUMAN
Immunogen Region: Internal
Accession Number: NP_036308.1; NP_277019.1
Specificity: This antibody is expected to recognize isoform 1 and 2 (NP_036308.1; NP_277019.1).
Immunogen Sequence: EHTSAVNKMFSRH
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome.
Protein Name F-Box Only Protein 4
Database Links Reactome: R-HSA-390471
Reactome: R-HSA-8951664
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-F-Box Only Protein 4 antibody
Anti-FBXO4 antibody
Anti-FBX4 antibody

Information sourced from Uniprot.org

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