| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBXO3 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBXO3 |
| Gene ID: |
26273 |
| Uniprot ID: |
FBX3_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human FBXO3 (NP_036307.2). |
| Immunogen Sequence: |
MAAMETETAPLTLESLPTDP LLLILSFLDYRDLINCCYVS RRLSQLSSHDPLWRRHCKKY WLISEEEKTQKNQCWKSLFI DTYSDVGRYIDHYAAIKKAW DDLKKYLEPRCPRMVLSLKE GAREEDLDAVEAQIGCKLPD DYRCSYRIHNGQKLVVPGLL GSMALSNHYRSEDLLDVDTA AGGFQQRQGLKYCLPLTFCI HTGLSQYIAVEAAEGRNKNE VFYQCPDQMARNPAAIDMF |
| Function | Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination. |
| Protein Name | F-Box Only Protein 3 |
| Cellular Localisation | NucleusColocalizes With Pml At The Peripheries Of Nuclear Bodies |
| Alternative Antibody Names | Anti-F-Box Only Protein 3 antibodyAnti-FBXO3 antibodyAnti-FBX3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
