Anti-FBXL4 antibody (396-446 aa) (STJ194532)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human FBXL4 at the amino acid range 396-446
General Information
| Short Description | Rabbit polyclonal anti-F-box/LRR-repeat protein 4 (396-446 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBXL4 |
| Gene ID | 26235 |
| Uniprot ID | FBXL4_HUMAN |
| Immunogen | Synthesized peptide derived from the human FBXL4 at the amino acid range 396-446 |
| Immunogen Region | 396-446 aa |
| Specificity | This antibody detects endogenous levels of FBXL4 at Human/Mouse |
Additional Info
| Function | Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors. Rescues also mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission. |
| Protein Name | F-Box/Lrr-Repeat Protein 4F-Box And Leucine-Rich Repeat Protein 4F-Box Protein Fbl4/Fbl5 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 4 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 4 antibodyAnti-F-Box Protein Fbl4/Fbl5 antibodyAnti-FBXL4 antibodyAnti-FBL4 antibodyAnti-FBL5 antibody |
Information sourced from Uniprot.org