| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXL12 |
| Gene ID: | 54850 |
| Uniprot ID: | FXL12_HUMAN |
| Immunogen Region: | 1-326 |
| Immunogen Sequence: | MATLVELPDSVLLEIFSYLP VRDRIRISRVCHRWKRLVDD RWLWRHVDLTLYTMRPKVMW HLLRRYMASRLHSLRMGGYL FSGSQAPQLSPALLRALGQK CPNLKRLCLHVADLSMVPIT SLPSTLRTLELHSCEISMAW LHKQQDPTVLPLLECIVLDR VPAFRDEHLQGLTRFRALRS LVLGGTYRVTETGLDAGLQE LSYLQRLEVLGCTLSADSTL LAISRHLRDVRKIRLTVRG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1). |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. |
| Protein Name | F-Box/Lrr-Repeat Protein 12F-Box And Leucine-Rich Repeat Protein 12F-Box Protein Fbl12 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 12 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 12 antibodyAnti-F-Box Protein Fbl12 antibodyAnti-FBXL12 antibodyAnti-FBL12 antibody |
Information sourced from Uniprot.org
