Anti-FBP2 antibody (1-339) (STJ116012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FBP2 (1-339) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBP2 |
| Gene ID | 8789 |
| Uniprot ID | F16P2_HUMAN |
| Immunogen Region | 1-339 |
| Immunogen Sequence | MTDRSPFETDMLTLTRYVME KGRQAKGTGELTQLLNSMLT AIKAISSAVRKAGLAHLYGI AGSVNVTGDEVKKLDVLSNS LVINMVQSSYSTCVLVSEEN KDAIITAKEKRGKYVVCFDP LDGSSNIDCLASIGTIFAIY RKTSEDEPSEKDALQCGRNI VAAGYALYGSATLVALSTGQ GVDLFMLDPALGEFVLVEKD VKIKKKGKIYSLNEGYAKYF DAATTEYVQKKKFPEDGSA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human FBP2 (NP_003828.2). |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle (at protein level). |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. |
| Protein Name | Fructose-1 -6-Bisphosphatase Isozyme 2Fbpase 2D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 2Muscle Fbpase |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | Cell JunctionCytoplasmNucleusMyofibrilSarcomereZ LineIn Neonatal CardiomyocytesDistributed Throughout The CytosolAccumulating In The Intercalated Disks Which Occur At The Z Line Of Cardiomyocytes And Connect Adjacent CellsAnd Also Located In The NucleusDissociates From The Z Line Following An Increase In Cytosolic Ca(2+) ConcentrationIn Muscle Precursor CellsLocalizes Predominantly To The Nucleus And To A Lesser Extent To The Cytoplasm At The Proliferative PhaseWhile Mainly Localizing To The Cytoplasm At The Differentiation PhaseColocalizes With Aldoa And Alpha-Actinin On Both Sides Of The Z Line Of Skeletal MuscleDissociates Rapidly From The Z Line Following An Increase In Cytosolic Ca(2+) Concentration |
| Alternative Antibody Names | Anti-Fructose-1 -6-Bisphosphatase Isozyme 2 antibodyAnti-Fbpase 2 antibodyAnti-D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 2 antibodyAnti-Muscle Fbpase antibodyAnti-FBP2 antibody |
Information sourced from Uniprot.org