Anti-FBP1 antibody [R04-5G6] (STJA0037117)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human FBP1
General Information
| Short Description | Rabbit monoclonal anti-FBP1 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-5G6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FBP1 |
| Gene ID | 2203 |
| Uniprot ID | F16P1_HUMAN |
| Immunogen | A synthesized peptide derived from human FBP1 |
Additional Info
| Tissue Specificity | Expressed in pancreatic islets. |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. |
| Protein Name | Fructose-1 -6-Bisphosphatase 1Fbpase 1D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1Liver Fbpase |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Fructose-1 -6-Bisphosphatase 1 antibodyAnti-Fbpase 1 antibodyAnti-D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 antibodyAnti-Liver Fbpase antibodyAnti-FBP1 antibodyAnti-FBP antibody |
Information sourced from Uniprot.org