Anti-FBN2 antibody (STJA0008297)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human fibrillin 2
General Information
| Short Description | Rabbit polyclonal anti-Fibrillin-2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBN2 |
| Gene ID | 2201 |
| Uniprot ID | FBN2_HUMAN |
| Immunogen | Synthesized peptide derived from human fibrillin 2 |
| Specificity | This antibody detects endogenous levels of fibrillin 2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels. |
| Protein Name | Fibrillin-2 Cleaved Into - Placensin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedFibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From CellsBut Are Subsequently Separated By FurinFibrillin-2: SecretedExtracellular SpaceExtracellular MatrixPlacensin: SecretedSecreted By Placental Cells |
| Alternative Antibody Names | Anti-Fibrillin-2 Cleaved Into - Placensin antibodyAnti-FBN2 antibody |
Information sourced from Uniprot.org