Anti-FBLN5 antibody (199-448) (STJ112002)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FBLN5 (199-448) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBLN5 |
| Gene ID | 10516 |
| Uniprot ID | FBLN5_HUMAN |
| Immunogen Region | 199-448 |
| Immunogen Sequence | NEDGRSCQDVNECATENPCV QTCVNTYGSFICRCDPGYEL EEDGVHCSDMDECSFSEFLC QHECVNQPGTYFCSCPPGYI LLDDNRSCQDINECEHRNHT CNLQQTCYNLQGGFKCIDPI RCEEPYLRISDNRCMCPAEN PGCRDQPFTILYRDMDVVSG RSVPADIFQMQATTRYPGAY YIFQIKSGNEGREFYMRQTG PISATLVMTRPIKGPREIQL DLEMITVNTVINFRGSSVI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2). |
Additional Info
| Tissue Specificity | Expressed in skin fibroblasts (at protein level). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes. |
| Post Translational Modifications | N-glycosylated. |
| Function | Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. |
| Protein Name | Fibulin-5Fibl-5Developmental Arteries And Neural Crest Egf-Like ProteinDanceUrine P50 ProteinUp50 |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Eln In Elastic Fibers |
| Alternative Antibody Names | Anti-Fibulin-5 antibodyAnti-Fibl-5 antibodyAnti-Developmental Arteries And Neural Crest Egf-Like Protein antibodyAnti-Dance antibodyAnti-Urine P50 Protein antibodyAnti-Up50 antibodyAnti-FBLN5 antibodyAnti-DANCE antibodyAnti-UNQ184 antibodyAnti-PRO210 antibody |
Information sourced from Uniprot.org