Anti-FBLN1 antibody (570-670) (STJ118486)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FBLN1 (570-670) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBLN1 |
| Gene ID | 2192 |
| Uniprot ID | FBLN1_HUMAN |
| Immunogen Region | 570-670 |
| Immunogen Sequence | RLPCHENRECSKLPLRITYY HLSFPTNIQAPAVVFRMGPS SAVPGDSMQLAITGGNEEGF FTTRKVSPHSGVVALTKPVP EPRDLLLTVKMDLSRHGTVS S |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 570-670 of human FBLN1 (NP_001987.2). |
Additional Info
| Tissue Specificity | Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells. |
| Function | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. |
| Protein Name | Fibulin-1Fibl-1 |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Fibulin-1 antibodyAnti-Fibl-1 antibodyAnti-FBLN1 antibodyAnti-PP213 antibody |
Information sourced from Uniprot.org