Anti-Fatty Acid Synthase antibody [2F9-B2-B6] (STJA0032354)

SKU:
STJA0032354
$184.23 - $388.47
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Short Description :Mouse monoclonal anti-Fatty Acid Synthase for use in WB, ICC, IF and IP in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ICC/IF/IP
Host:Mouse
Reactivity:Human/Mouse/Rat/Monkey
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :2F9-B2-B6
Isotype:IgG2a
Conjugation:Unconjugated
Concentration:2.285 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
IF 1:50-1:200
IP 1:20
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:FASN
Gene ID:2194
Uniprot ID:FAS_HUMAN
Immunogen:Purified recombinant human Fatty Acid Synthase protein fragments expressed in E.coli.
Tissue Specificity Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.
Post Translational Modifications S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.
Function Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein (ACP) domain. (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.
Protein Name Fatty Acid Synthase
Type I Fatty Acid Synthase Includes - Acyl-Carrier-Protein S-Acetyltransferase - Acyl-Carrier-Protein S-Malonyltransferase - 3-Oxoacyl-Acyl-Carrier-Protein Synthase - 3-Oxoacyl-Acyl-Carrier-Protein Reductase - 3-Hydroxyacyl-Acyl-Carrier-Protein Dehydratase - Enoyl-Acyl-Carrier-Protein Reductase - Acyl-Acyl-Carrier-Protein Hydrolase
Database Links Reactome: R-HSA-163765
Reactome: R-HSA-199220
Reactome: R-HSA-2426168
Reactome: R-HSA-75105
Reactome: R-HSA-9029558
Cellular Localisation Cytoplasm
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Antibody Names Anti-Fatty Acid Synthase antibody
Anti-Type I Fatty Acid Synthase Includes - Acyl-Carrier-Protein S-Acetyltransferase - Acyl-Carrier-Protein S-Malonyltransferase - 3-Oxoacyl-Acyl-Carrier-Protein Synthase - 3-Oxoacyl-Acyl-Carrier-Protein Reductase - 3-Hydroxyacyl-Acyl-Carrier-Protein Dehydratase - Enoyl-Acyl-Carrier-Protein Reductase - Acyl-Acyl-Carrier-Protein Hydrolase antibody
Anti-FASN antibody
Anti-FAS antibody

Information sourced from Uniprot.org