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Anti-Fascin antibody [SM5027] (STJA0005027)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human Fascin
General Information
| Short Description | Mouse monoclonal anti-Fascin for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5027 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | FSCN1 |
| Gene ID | 6624 |
| Uniprot ID | FSCN1_HUMAN |
| Immunogen | Synthesized peptide derived from human Fascin |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin55 Kda Actin-Bundling ProteinSinged-Like ProteinP55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | CytoplasmCytosolCell CortexCytoskeletonStress FiberCell ProjectionFilopodiumInvadopodiumMicrovillusCell JunctionColocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth ConeColocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibodyAnti-55 Kda Actin-Bundling Protein antibodyAnti-Singed-Like Protein antibodyAnti-P55 antibodyAnti-FSCN1 antibodyAnti-FAN1 antibodyAnti-HSN antibodyAnti-SNL antibody |
Information sourced from Uniprot.org