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![Anti-Fascin antibody [IM20] (STJ16101740)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152246/347096/STJ16101740_1__64986.1681999361.jpg?c=1 "Anti-Fascin antibody [IM20] (STJ16101740)")
Anti-Fascin antibody [IM20] (STJ16101740)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenProkaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule.
General Information
| Short Description | Mouse monoclonal anti-Fascin for use in IHC-P and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IM20 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | IHC-P 1:200-1:400WB 1:100-1:200 |
| Formulation | Tissue culture supernatant with 15 mM Sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | FSCN1 |
| Gene ID | 6624 |
| Uniprot ID | FSCN1_HUMAN |
| Immunogen | Prokaryotic recombinant protein corresponding to the C-terminal region of the fascin molecule. |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin55 Kda Actin-Bundling ProteinSinged-Like ProteinP55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | CytoplasmCytosolCell CortexCytoskeletonStress FiberCell ProjectionFilopodiumInvadopodiumMicrovillusCell JunctionColocalized With Rufy3 And F-Actin At Filipodia Of The Axonal Growth ConeColocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibodyAnti-55 Kda Actin-Bundling Protein antibodyAnti-Singed-Like Protein antibodyAnti-P55 antibodyAnti-FSCN1 antibodyAnti-FAN1 antibodyAnti-HSN antibodyAnti-SNL antibody |
Information sourced from Uniprot.org