Anti-FANCM antibody (440-490 aa) (STJ190816)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein at the amino acid 440-490
General Information
| Short Description | Rabbit polyclonal anti-Fanconi anemia group M protein (440-490 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FANCM |
| Gene ID | 57697 |
| Uniprot ID | FANCM_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein at the amino acid 440-490 |
| Immunogen Region | 440-490 aa |
| Specificity | FANCM Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated.hyperphosphorylated in response to genotoxic stress. |
| Function | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. |
| Protein Name | Fanconi Anemia Group M ProteinProtein FacmAtp-Dependent Rna Helicase FancmFanconi Anemia-Associated Polypeptide Of 250 KdaFaap250Protein Hef Ortholog |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Fanconi Anemia Group M Protein antibodyAnti-Protein Facm antibodyAnti-Atp-Dependent Rna Helicase Fancm antibodyAnti-Fanconi Anemia-Associated Polypeptide Of 250 Kda antibodyAnti-Faap250 antibodyAnti-Protein Hef Ortholog antibodyAnti-FANCM antibodyAnti-KIAA1596 antibody |
Information sourced from Uniprot.org