| Short Description : | Goat polyclonal antibody anti-FANCL (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | Pep-ELISA/WB |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 45kDa band observed in Human Bone Marrow lysates (calculated MW of 43.4kDa according to NP_001108108.1). Recommended concentration: 1-3µg/ml. |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | FANCL |
| Gene ID: | 55120 |
| Uniprot ID: | FANCL_HUMAN |
| Accession Number: | NP_001108108.1; NP_060532.2 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | QNLKDVLEIDFP |
| Specificity: | This antibody is expected to recognize both isoforms (NP_001108108.1; NP_060532.2). |
| Function | Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. |
| Protein Name | E3 Ubiquitin-Protein Ligase FanclFanconi Anemia Group L ProteinFanconi Anemia-Associated Polypeptide Of 43 KdaFaap43Ring-Type E3 Ubiquitin Transferase Fancl |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Fancl antibodyAnti-Fanconi Anemia Group L Protein antibodyAnti-Fanconi Anemia-Associated Polypeptide Of 43 Kda antibodyAnti-Faap43 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Fancl antibodyAnti-FANCL antibodyAnti-PHF9 antibody |
Information sourced from Uniprot.org
