| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CIAO2B |
| Gene ID: | 51647 |
| Uniprot ID: | CIA2B_HUMAN |
| Immunogen Region: | 1-163 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human FAM96B (NP_057146.1). |
| Immunogen Sequence: | MVGGGGVGGGLLENANPLIY QRSGERPVTAGEEDEQVPDS IDAREIFDLIRSINDPEHPL TLEELNVVEQVRVQVSDPES TVAVAFTPTIPHCSMATLIG LSIKVKLLRSLPQRFKMDVH ITPGTHASEHAVNKQLADKE RVAAALENTHLLEVVNQCLS ARS |
| Function | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. |
| Protein Name | Cytosolic Iron-Sulfur Assembly Component 2b Mss19-Interacting Protein Of 18 Kda Mitotic Spindle-Associated Mmxd Complex Subunit Mip18 Protein Fam96b |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Spindle Midbody In Mitosis Localizes To The Spindle During Metaphase And The Spindle Midbody During Telophase Co-Localizes With Kif4a To The Spindle Midzone And Midbody During Telophase And Cytokinesis |
| Alternative Antibody Names | Anti-Cytosolic Iron-Sulfur Assembly Component 2b antibody Anti-Mss19-Interacting Protein Of 18 Kda antibody Anti-Mitotic Spindle-Associated Mmxd Complex Subunit Mip18 antibody Anti-Protein Fam96b antibody Anti-CIAO2B antibody Anti-CIAB antibody Anti-FAM96B antibody Anti-MIP18 antibody Anti-CGI-128 antibody Anti-HSPC118 antibody |
Information sourced from Uniprot.org