| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FAM120A |
| Gene ID: | 23196 |
| Uniprot ID: | F120A_HUMAN |
| Immunogen Region: | 1-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human FAM120A (NP_055427.2). |
| Immunogen Sequence: | MGVQGFQDYIEKHCPSAVVP VELQKLARGSLVGGGRQRPP QTPLRLLVDADNCLHRLYGG FYTDWVSGGQWNHMLGYLAA LAKACFGGNIELFVFFNGAL EKARLHEWVKRQGNERQTAQ QIVSHVQNKGTPPPKVWFLP |
| Tissue Specificity | Widely expressed. In gastric mucosa, detected in the bottom region of the foveolar epithelium (at protein level). |
| Post Translational Modifications | Arg-982 is dimethylated, probably to asymmetric dimethylarginine. Phosphorylated on tyrosine by SRC family protein kinases upon oxidative stress, for instance following UV irradiation. |
| Function | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases. May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase. Binds IGF2 RNA and promotes the production of IGF2 protein. |
| Protein Name | Constitutive Coactivator Of Ppar-Gamma-Like Protein 1 Oxidative Stress-Associated Src Activator Protein Fam120a |
| Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Translocates From The Cytosol To Plasma Membrane After Uv Irradiation |
| Alternative Antibody Names | Anti-Constitutive Coactivator Of Ppar-Gamma-Like Protein 1 antibody Anti-Oxidative Stress-Associated Src Activator antibody Anti-Protein Fam120a antibody Anti-FAM120A antibody Anti-C9orf10 antibody Anti-KIAA0183 antibody Anti-OSSA antibody |
Information sourced from Uniprot.org
