Anti-FAM107A antibody (STJA0007363)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FAM107A
General Information
| Short Description | Rabbit polyclonal anti-Actin-associated protein FAM107A for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FAM107A |
| Gene ID | 11170 |
| Uniprot ID | F107A_HUMAN |
| Immunogen | Synthesized peptide derived from human FAM107A |
| Specificity | This antibody detects endogenous levels of FAM107A at Human |
Additional Info
| Function | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization.negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development. |
| Protein Name | Actin-Associated Protein Fam107aDown-Regulated In Renal Cell Carcinoma 1Protein Tu3a |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonStress FiberCell JunctionFocal AdhesionCell ProjectionRuffle MembraneSynapseColocalizes With F-Actin And Commd1 In The NucleusColocalizes With Map1a Along Actin Stress Fibers And Membrane Ruffles |
| Alternative Antibody Names | Anti-Actin-Associated Protein Fam107a antibodyAnti-Down-Regulated In Renal Cell Carcinoma 1 antibodyAnti-Protein Tu3a antibodyAnti-FAM107A antibodyAnti-DRR1 antibodyAnti-TU3A antibody |
Information sourced from Uniprot.org