Anti-FALZ/BPTF IP antibody [SAA0188] (STJA0018703)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Mouse monoclonal Nucleosome-Remodeling Factor Subunit Bptf antibody for use in ELISA, IF and IP in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IF/IP |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0188 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | BPTF |
| Gene ID | 2186 |
| Uniprot ID | BPTF_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis. |
| Function | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors. |
| Protein Name | Nucleosome-Remodeling Factor Subunit BptfBromodomain And Phd Finger-Containing Transcription FactorFetal Alz-50 Clone 1 ProteinFetal Alzheimer Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes To Sites Of Dna DamageIn Brains Of Alzheimer Disease PatientsPresent In A Subset Of Amyloid-Containing Plaques |
| Alternative Antibody Names | Anti-Nucleosome-Remodeling Factor Subunit Bptf antibodyAnti-Bromodomain And Phd Finger-Containing Transcription Factor antibodyAnti-Fetal Alz-50 Clone 1 Protein antibodyAnti-Fetal Alzheimer Antigen antibodyAnti-BPTF antibodyAnti-FAC1 antibodyAnti-FALZ antibody |
Information sourced from Uniprot.org