| Function | Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA. |
| Protein Name | Oxaloacetate Tautomerase Fahd1 - MitochondrialAcylpyruvase Fahd1Fumarylacetoacetate Hydrolase Domain-Containing Protein 1Fah Domain-Containing Protein 1Oxaloacetate DecarboxylaseOaa DecarboxylaseOdxYisk-Like Protein |
| Database Links | Reactome: R-HSA-70268 |
| Cellular Localisation | MitochondrionCytoplasmCytosol |
| Alternative Antibody Names | Anti-Oxaloacetate Tautomerase Fahd1 - Mitochondrial antibodyAnti-Acylpyruvase Fahd1 antibodyAnti-Fumarylacetoacetate Hydrolase Domain-Containing Protein 1 antibodyAnti-Fah Domain-Containing Protein 1 antibodyAnti-Oxaloacetate Decarboxylase antibodyAnti-Oaa Decarboxylase antibodyAnti-Odx antibodyAnti-Yisk-Like Protein antibodyAnti-FAHD1 antibodyAnti-C16orf36 antibodyAnti-YISKL antibody |
Information sourced from Uniprot.org
