Anti-FADD antibody (20-150) [S7MR] (STJ11101587)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FADD (20-150) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FADD |
| Gene ID | 8772 |
| Uniprot ID | FADD_HUMAN |
| Immunogen Region | 20-150 |
| Immunogen Sequence | LTELKFLCLGRVGKRKLERV QSGLDLFSMLLEQNDLEPGH TELLRELLASLRRHDLLRRV DDFEAGAAAGAAPGEEDLCA AFNVICDNVGKDWRRLARQL KVSDTKIDSIEDRYPRNLTE RVRESLRIWKN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human FADD (Q13158). |
Additional Info
| Tissue Specificity | Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. |
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. |
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinGrowth-Inhibiting Gene 3 ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-2562578Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5675482Reactome: R-HSA-69416Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-9013957Reactome: R-HSA-933543Reactome: R-HSA-9693928 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Fas-Associated Death Domain Protein antibodyAnti-Fas-Associating Death Domain-Containing Protein antibodyAnti-Growth-Inhibiting Gene 3 Protein antibodyAnti-Mediator Of Receptor Induced Toxicity antibodyAnti-FADD antibodyAnti-MORT1 antibodyAnti-GIG3 antibody |
Information sourced from Uniprot.org