Anti-F8 antibody (21-300 aa) (STJ11106087)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal F8 (21-300 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | F8 |
| Gene ID | 2157 |
| Uniprot ID | FA8_HUMAN |
| Immunogen Region | 21-300 aa |
| Immunogen Sequence | TRRYYLGAVELSWDYMQSDL GELPVDARFPPRVPKSFPFN TSVVYKKTLFVEFTDHLFNI AKPRPPWMGLLGPTIQAEVY DTVVITLKNMASHPVSLHAV GVSYWKASEGAEYDDQTSQR EKEDDKVFPGGSHTYVWQVL KENGPMASDPLCLTYSYLSH VDLVKDLNSGLIGALLVCRE GSLAKEKTQTLHKFILLFAV FDEGKSWHSETKNSLMQDRD AASARAWPKMHTVNGYVNR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human F8 (NP_000123.1). |
Additional Info
| Post Translational Modifications | Sulfation on Tyr-1699 is essential for binding vWF. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form. |
| Function | Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
| Protein Name | Coagulation Factor ViiiAntihemophilic FactorAhfProcoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-163841Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-9672383Reactome: R-HSA-9672387Reactome: R-HSA-9672391Reactome: R-HSA-9672393Reactome: R-HSA-9672395Reactome: R-HSA-9672396Reactome: R-HSA-9672397Reactome: R-HSA-9673202Reactome: R-HSA-9674519 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Coagulation Factor Viii antibodyAnti-Antihemophilic Factor antibodyAnti-Ahf antibodyAnti-Procoagulant Component Cleaved Into - Factor Viiia Heavy Chain - 200 Kda Isoform - Factor Viiia Heavy Chain - 92 Kda Isoform - Factor Viii B Chain - Factor Viiia Light Chain antibodyAnti-F8 antibodyAnti-F8C antibody |
Information sourced from Uniprot.org