Anti-F5 antibody (300-510) (STJ118027)

Name: Anti-F5 antibody (300-510) (STJ118027)
SKU: STJ118027
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118027

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Short Description	Rabbit polyclonal F5 (300-510) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	F5
Gene ID	2153
Uniprot ID	FA5_HUMAN
Immunogen Region	300-510
Immunogen Sequence	VGPEGKWIISSLTPKHLQAG MQAYIDIKNCPKKTRNLKKI TREQRRHMKRWEYFIAAEEV IWDYAPVIPANMDKKYRSQH LDNFSNQIGKHYKKVMYTQY EDESFTKHTVNPNMKEDGIL GPIIRAQVRDTLKIVFKNMA SRPYSIYPHGVTFSPYEDEV NSSFTSGRNNTMIRAVQPGE TYTYKWNILEFDEPTENDAQ CLTRPYYSDVD
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 300-510 of human F5 (NP_000121.2).

Tissue Specificity	Plasma.
Post Translational Modifications	Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylated by FAM20C in the extracellular medium.
Function	Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Protein Name	Coagulation Factor V Activated Protein C Cofactor Proaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-140875 Reactome: R-HSA-204005 Reactome: R-HSA-381426 Reactome: R-HSA-5694530 Reactome: R-HSA-8957275
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Coagulation Factor V antibody Anti-Activated Protein C Cofactor antibody Anti-Proaccelerin - Labile Factor Cleaved Into - Coagulation Factor V Heavy Chain - Coagulation Factor V Light Chain antibody Anti-F5 antibody

Information sourced from Uniprot.org