Anti-EYA2 antibody [R01-6A1] (STJA0035196)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human EYA2
General Information
| Short Description | Rabbit monoclonal anti-EYA2 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-6A1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EYA2 |
| Gene ID | 2139 |
| Uniprot ID | EYA2_HUMAN |
| Immunogen | A synthetic peptide of human EYA2 |
Additional Info
| Tissue Specificity | Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart. |
| Function | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2.in this it is functionally redundant with EYA1. |
| Protein Name | Protein Phosphatase Eya2Eyes Absent Homolog 2 |
| Database Links | Reactome: R-HSA-5693565 |
| Cellular Localisation | CytoplasmNucleusRetained In The Cytoplasm Via Interaction With Gnaz And Gnai2Interaction With Six1Six2Six4 Or Six5 Is Required For Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Protein Phosphatase Eya2 antibodyAnti-Eyes Absent Homolog 2 antibodyAnti-EYA2 antibodyAnti-EAB1 antibody |
Information sourced from Uniprot.org