Anti-EXTL3 antibody (STJ192125)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Exostosin-like 3 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EXTL3 |
| Gene ID | 2137 |
| Uniprot ID | EXTL3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | EXTL3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion. Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REG3A and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death. |
| Protein Name | Exostosin-Like 3Ext-Related Protein 1Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-AcetylglucosaminyltransferaseHereditary Multiple Exostoses Gene IsologMultiple Exostosis-Like Protein 3Putative Tumor Suppressor Protein Extl3 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCell MembraneNucleusInteraction With Reg3a Induces Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Exostosin-Like 3 antibodyAnti-Ext-Related Protein 1 antibodyAnti-Glucuronyl-Galactosyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase antibodyAnti-Hereditary Multiple Exostoses Gene Isolog antibodyAnti-Multiple Exostosis-Like Protein 3 antibodyAnti-Putative Tumor Suppressor Protein Extl3 antibodyAnti-EXTL3 antibodyAnti-EXTL1L antibodyAnti-EXTR1 antibodyAnti-KIAA0519 antibody |
Information sourced from Uniprot.org