Anti-EXOSC5 antibody (STJA0008400)

SKU:
STJA0008400

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Exosome complex component RRP46 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EXOSC5
Gene ID: 56915
Uniprot ID: EXOS5_HUMAN
Specificity: This antibody detects endogenous levels of EXOSC5 at Human, Mouse
Immunogen: Synthesized peptide derived from human EXOSC5
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity.
Protein Name Exosome Complex Component Rrp46
Chronic Myelogenous Leukemia Tumor Antigen 28
Exosome Component 5
Ribosomal Rna-Processing Protein 46
P12b
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-429958
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-450604
Reactome: R-HSA-6791226
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
Alternative Antibody Names Anti-Exosome Complex Component Rrp46 antibody
Anti-Chronic Myelogenous Leukemia Tumor Antigen 28 antibody
Anti-Exosome Component 5 antibody
Anti-Ribosomal Rna-Processing Protein 46 antibody
Anti-P12b antibody
Anti-EXOSC5 antibody
Anti-CML28 antibody
Anti-RRP46 antibody

Information sourced from Uniprot.org

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