| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EXOSC4 (1-245) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EXOSC4 |
| Gene ID: |
54512 |
| Uniprot ID: |
EXOS4_HUMAN |
| Immunogen Region: |
1-245 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EXOSC4 (NP_061910.1). |
| Immunogen Sequence: |
MAGLELLSDQGYRVDGRRAG ELRKIQARMGVFAQADGSAY IEQGNTKALAVVYGPHEIRG SRARALPDRALVNCQYSSAT FSTGERKRRPHGDRKSCEMG LQLRQTFEAAILTQLHPRSQ IDIYVQVLQADGGTYAACVN AATLAVLDAGIPMRDFVCAC SAGFVDGTALADLSHVEEAA GGPQLALALLPASGQIALLE MDARLHEDHLERVLEAAAQA ARDVHTLLDRVVRQHVREA |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. |
| Protein Name | Exosome Complex Component Rrp41Exosome Component 4Ribosomal Rna-Processing Protein 41P12a |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429958Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-450604Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolus |
| Alternative Antibody Names | Anti-Exosome Complex Component Rrp41 antibodyAnti-Exosome Component 4 antibodyAnti-Ribosomal Rna-Processing Protein 41 antibodyAnti-P12a antibodyAnti-EXOSC4 antibodyAnti-RRP41 antibodyAnti-SKI6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
