| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EXOSC10 (586-885) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EXOSC10 |
| Gene ID: |
5394 |
| Uniprot ID: |
EXOSX_HUMAN |
| Immunogen Region: |
586-885 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1). |
| Immunogen Sequence: |
VAAGVKKSGPLPSAERLENV LFGPHDCSHAPPDGYPIIPT SGSVPVQKQASLFPDEKEDN LLGTTCLIATAVITLFNEPS AEDSKKGPLTVAQKKAQNIM ESFENPFRMFLPSLGHRAPV SQAAKFDPSTKIYEISNRWK LAQVQVQKDSKEAVKKKAAE QTAAREQAKEACKAAAEQAI SVRQQVVLENAAKKRERATS DPRTTEQKQEKKRLKISKKP KDPEPPEKEFTPYDYSQSD |
| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. |
| Protein Name | Exosome Complex Component 10Autoantigen Pm/Scl 2P100 Polymyositis-Scleroderma Overlap Syndrome-Associated AutoantigenPolymyositis/Scleroderma Autoantigen 100 KdaPm/Scl-100Polymyositis/Scleroderma Autoantigen 2 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolusStrongly Enriched In The Nucleolus And A Small Amount Has Been Found In Cytoplasm Supporting The Existence Of A Nucleolar Rna Exosome Complex Form |
| Alternative Antibody Names | Anti-Exosome Complex Component 10 antibodyAnti-Autoantigen Pm/Scl 2 antibodyAnti-P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen antibodyAnti-Polymyositis/Scleroderma Autoantigen 100 Kda antibodyAnti-Pm/Scl-100 antibodyAnti-Polymyositis/Scleroderma Autoantigen 2 antibodyAnti-EXOSC10 antibodyAnti-PMSCL antibodyAnti-PMSCL2 antibodyAnti-RRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
